2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Na+/Ca2+ Exchanger

Na+/Ca2+ Exchanger

Na+/Ca2+ Exchanger

Related Products

PDF 0.23 MB

Na+/Ca2+ exchanger (sodium-calcium exchanger , NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). Na+/Ca2+ exchanger removes a single calcium ion in exchange for the import of three sodium ions. Na+/Ca2+ exchanger exists in many different cell types and animal species. Na+/Ca2+ exchanger is considered one of the most important cellular mechanisms for removing Ca2+. The Na+/Ca2+ exchanger does not bind very tightly to Ca2+ (has a low affinity), but it can transport the ions rapidly (has a high capacity), transporting up to five thousand Ca2+ ions per second. The Na+/Ca2+ exchanger also likely plays an important role in regaining the cell's normal calcium concentrations after an excitotoxic insult.

Na+/Ca2+ Exchanger Related Products (22):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15754
    CGP37157
    		Inhibitor 99.87%
    CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria, with an IC50 of 0.8 μM.
    CGP37157
  • HY-B1193
    Terfenadine
    		Activator 99.98%
    Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
    Terfenadine
  • HY-101044
    PPADS tetrasodium
    		Inhibitor
    PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle.
    PPADS tetrasodium
  • HY-15515
    SEA0400
    		Inhibitor 99.95%
    SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
    SEA0400
  • HY-15415
    KB-R7943 mesylate
    		Inhibitor 99.16%
    KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.
    KB-R7943 mesylate
  • HY-B1546A
    Benzamil hydrochloride
    		Inhibitor 99.70%
    Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
    Benzamil hydrochloride
  • HY-107658
    SN 6
    		Inhibitor 99.79%
    SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, and inhibits 45Ca2+ uptake by NCX1, NCX2, and NCX3, with IC50s of 2.9, 16, and 8.6 μM, respectively.
    SN 6
  • HY-123785
    ORM-10962
    		Inhibitor 99.49%
    ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively. ORM-10962 shows antiarrhythmic effect.
    ORM-10962
  • HY-136182A
    YM-244769
    		Inhibitor 99.22%
    YM-244769 is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice.
    YM-244769
  • HY-128678
    ORM-10103
    		Inhibitor 99.43%
    ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively.
    ORM-10103
  • HY-136182
    YM-244769 dihydrochloride
    		Inhibitor 98.57%
    YM-244769 dihydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.
    YM-244769 dihydrochloride
  • HY-B1193R
    Terfenadine (Standard)
    		Activator
    Terfenadine (Standard) is the analytical standard of Terfenadine. This product is intended for research and analytical applications. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
    Terfenadine (Standard)
  • HY-107659
    YM-244769 hydrochloride
    		Inhibitor 99.02%
    YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.
    YM-244769 hydrochloride
  • HY-100298
    Caldaret
    		Inhibitor 98.35%
    Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.
    Caldaret
  • HY-P10811
    Na2+ - Ca2+ Exchanger inhibitory peptide
    		Inhibitor
    Na+-Ca2+ Exchanger inhibitory peptide (XIP) is a Na+-Ca2+ exchanger inhibitor with a Ki of 200 nM. Na+-Ca2+ Exchanger inhibitory peptide inhibits the Na+-dependent Ca2+ uptake and the Na+-dependent Ca2+ efflux of sarcolemmal vesicles in a noncompetitive manner.
    Na2+ - Ca2+ Exchanger inhibitory peptide
  • HY-138947
    KB-R7943
    		Inhibitor
    KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC50 value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models.
    KB-R7943
  • HY-B1546
    Benzamil
    		Inhibitor
    Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
    Benzamil
  • HY-164684
    Dichlorobenzamil
    		Inhibitor
    Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits 45Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC50 = 18 μM). Dichlorobenzamil can also block K+ channels and voltage-sensitive Ca2+ channels.
    Dichlorobenzamil
  • HY-B1193S
    Terfenadine-d3
    Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
    Terfenadine-d3
  • HY-B1546AR
    Benzamil hydrochloride (Standard)
    		Inhibitor
    Benzamil (hydrochloride) (Standard) is the analytical standard of Benzamil (hydrochloride). This product is intended for research and analytical applications. Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
    Benzamil hydrochloride (Standard)